Projects

BioCEL Animations

General lab operation Safety (Eldi) (video) Pipetting (Eldi) (video) High level process of design and implementation of a simple circuit Use Benchling or other software for DNA management (Eldi) Gateway Setup Gateway reaction (Eldi) Demonstration of Gateway protocol (video) Bacterial transformation (Eldi) Traditional cloning and bacteria transformation. Has downloadable flash file which is easy to […]

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Studying network perturbations in disease states

Studying network perturbations in disease states

Synthetic biology provides novel tools for elucidating previously unknown or difficult-to-study principles that underlie diseases. Here, we aim to leverage these tools to achieve breakthroughs in our scientific knowledge: Using two-component signaling systems in bacteria, we will elucidate the molecular mechanisms which define protein-protein specificity and translate these mechanisms into computational tools. Using PHO promoters […]

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Engineering scalable synthetic networks

Engineering scalable synthetic networks

We are developing to establish key frameworks that enable scalable construction of biological systems, a breakthrough capability that will be broadly enabling for basic biology, biotechnology, and human health.  Our goals are as follows: Engineer scalable synthetic tools – protein-DNA circuits for transcriptional control, RNA-based devices that are programmable based on nucleic acid systems, and […]

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Targeting malfunctioning biological systems in key diseases

Targeting malfunctioning biological systems in key diseases

We are working to address these problems with systems-level approaches using synthetic RNA-based circuits to sense, compute, and destroy cancerous cells, programmable differentiation of stem cells into insulin-producing beta-islet cells for diabetes, and synthetic engineered viruses to target antibiotic-resistant bacteria. Specifically, we aim to develop the following: Develop novel RNAi-based circuits to detect and destroy […]

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